Health E-Insights

An Interview with Dr. Ian Cook

By Sheldon Baker | June 8, 2012

Dr. Ian Cook, M.D., is a senior medical advisor to NeuroSigma and one of the inventors of Trigeminal Nerve Stimulation. Dr. Cook is also a professor of psychiatry and biobehavioral sciences at UCLA and director of the UCLA depression research & clinic program. NeuroSigma, Inc. is a Los Angeles-based medical device company.

Dr. Ian Cook, M.D., is a senior medical advisor to NeuroSigma and one of the inventors of Trigeminal Nerve Stimulation. Dr. Cook is also a professor of psychiatry and biobehavioral sciences at UCLA and director of the UCLA depression research & clinic program. NeuroSigma, Inc. is a Los Angeles-based medical device company. The website is: http://www.neurosigma.com/
 

Health E-Insights: How serious is depression in Americans today?
 
Dr. Cook: Major Depression (clinical depression) is common and disabling. Beyond the sadness that gives the disorder its name, there are impairments in concentration, decision making, sleep, energy and anxiety. Over 20 million Americans will have major depression this year, and one in six will have it at some point in their lives. About every 14 minutes, someone in the US dies from suicide, most from mood disorders. In the years prior to the recession, American business lost over $40 billion each year due to disability from major depression, and costs of care added another $40 billion-plus.
 
Health E-Insights: Does it lead to other illnesses?
 
Dr. Cook: Depression worsens the outcome for many other illnesses. For example, people who have a heart attack and have depression are much more likely to die within a year than those not depressed.  Treatment results are poorer in diabetes, AIDS, cancer, and many other serious illnesses.
 
Health E-Insights: Have economic woes lead to increased depression in the U.S.?
 
Dr. Cook: Anything that adds to stress has potential for increasing the risk of depression, at least in some people. The CDC's most recent estimates are that 1 in 10 Americans takes an antidepressant medication, and yet less than half of those with severe depression are taking an antidepressant. It's hard to establish cause-and-effect with the economy, but some numbers have grown over recent years.
 
Health E-Insights: What is the science behind eTNS, how does it work?
 
Dr. Cook: eTNS has been shown to modulate, or alter, the activity in key brain areas, including those involved mood, emotion, attention, and concentration, and also in controlling seizures. These changes may be important parts of how eTNS leads to clinical benefits.  The eTNS device, developed by NeuroSigma, includes a conductive adhesive patch that goes on the forehead and connects to a generator that is the size of a cell phone.  The patch stimulates branches of the trigeminal nerve, which are located very close to the surface of the skin of the forehead.  Patients wear this device while they sleep, approximately 8 hours per night, and their mood is improved throughout the day.
 
Health E-Insights: In clinical studies, how did people respond to the device?
 
Dr. Cook: In studies of eTNS in drug-resistant epilepsy, over 40% of people using the device had a marked (≥50%) decrease in seizures, vs. only 16% in people who used a sham or placebo device. In an open trial in depression that had not responded to medication, 64% of people experienced marked (≥50%) decreases in depressive symptom severity.
 
Health E-Insights: For eTNS, how depressed were people when they started using the device?
 
Dr. Cook: On average, symptoms were in the moderate to severe range. All had tried medications before, with between 2 and 18 failed trials in the current bout of depression.
 
Health E-Insights: What are the next steps for treatment?
 
Dr. Cook: The next step is the completion of a on-going Phase II clinical trial being conducted under double blind conditions, in which neither the participants nor the doctors and staff know who is receiving active eTNS or a control (sham or placeb) treatment). This can help determine how much better eTNS can benefit patients than placebo treatment. FDA approval is required before eTNS can be available in the U.S.
 
Sheldon Baker is well-known for creating nutraceutical brand marketing and public relations campaigns. For Health E-Insights interview consideration, contact him at Baker@CentralValleyTalk.com. And follow him on Twitter @NutraInk.
 
 

Related Health Conditions:

Related Market Segments:

blog comments powered by Disqus
  • An Interview with Steven Feinberg of Mid America Food Sales

    An Interview with Steven Feinberg of Mid America Food Sales

    Sheldon Baker||March 1, 2016
    Steven Feinberg was born and raised in Chicago and currently lives in Deerfield, IL, with his wife and business partner Judy.

  • An Interview with Romain Caillard of NutraJIT

    An Interview with Romain Caillard of NutraJIT

    Sheldon Baker||January 5, 2016
    Romain Caillard is chief scientific officer for NutraJIT.

  • An Interview with Adina Mayerhoff of Nucentric Nutrition

    An Interview with Adina Mayerhoff of Nucentric Nutrition

    Sheldon Baker||December 3, 2015
    Adina Mayerhoff, MS, RDN is president of Nucentric Nutrition, Inc., in Boca Raton, FL.

  • An Interview with Jennfier Gu of AIDP

    An Interview with Jennfier Gu of AIDP

    Sheldon Baker||November 2, 2015
    Dr. Jennifer Gu, is the director of research and development for AIDP and heads the branded ingredient department.

  • An Interview with Tami Wahl of AHPA

    An Interview with Tami Wahl of AHPA

    Sheldon Baker||October 1, 2015
    Tami L. Wahl is the special regulatory counsel at the American Herbal Products Association (AHPA).

  • An Interview with Ajay Patel of Verdure Sciences

    An Interview with Ajay Patel of Verdure Sciences

    Sheldon Baker||September 8, 2015
    Verdure Sciences was founded by Ajay Patel in 1997.

  • An Interview with R.M. (Dick) Griffin of NFP Property & Casualty Services

    An Interview with R.M. (Dick) Griffin of NFP Property & Casualty Services

    Sheldon Baker||July 1, 2015
    Mr Griffin was formerly the owner of Grifcon Enterprises, a leading dietary supplement insurance agency.

  • An Interview with Lisa Marie of ReddRox and PASS4kids

    An Interview with Lisa Marie of ReddRox and PASS4kids

    Sheldon Baker||June 1, 2015
    Lisa Marie is CEO/founder of ReddRox, Inc. and heads PASS4kids, a movement to help end obesity, cancer and diabetes.

  • An Interview with Len Zapalowski

    An Interview with Len Zapalowski

    Sheldon Baker, NutraInk||October 1, 2014
    CEO with Mazza Innovation has more than 25 years of senior management experience.

  • An Interview with Dr. Daniel Fabricant

    An Interview with Dr. Daniel Fabricant

    Sheldon Baker, NutraInk||September 1, 2014
    Dr. Daniel Fabricant is the executive director and CEO of the Natural Products Association (NPA).

  • An Interview with Luke Huber, ND, MBA

    An Interview with Luke Huber, ND, MBA

    Sheldon Baker||October 1, 2013
    Luke Huber, ND, MBA, is vice president of product innovation and scientific development for Life Extension in Fort Lauderdale, FL.

  • An interview with Dr. Stephen Sinatra

    An interview with Dr. Stephen Sinatra

    Sheldon Baker||May 1, 2013
    Stephen T. Sinatra, MD, FACC, is a board-certified cardiologist and certified psychotherapist with 40 years of clinical experience treating, preventing and reversing heart disease.

  • An interview with Sue Zawacki

    An interview with Sue Zawacki

    Sheldon Baker||January 1, 2013
    Aging Info Radio host Sue Billings Zawacki's direct contact with seniors and families through her work in the insurance industry made her aware of the issues that adult children of aging parents face when trying to find the right resources to assist their loved ones.

  • An interview with Mark Whitacre

    An interview with Mark Whitacre

    Sheldon Baker||November 1, 2012

  • An Interview with Jeffery Burke

    An Interview with Jeffery Burke

    Sheldon Baker||September 21, 2012
    Jeffrey Burke is a naturopath and master herbalist based in Las Vegas, NV. He has been in the health and nutrition field for three decadesand hosted the Staying Healthy! radio show on KLAV-AM for over 28 years.

  • An Interview with Audrey Holocher

    An Interview with Audrey Holocher

    Sheldon Baker||September 7, 2012
    Audrey Holocheris president and founder of storied research inc. Holocher’s professional experience is multi-storied. She draws from the fields of narrative consulting, qualitative market research, branding, advertising, and the social, physical and life sciences. In her work as a consultant to branding and advertising agencies, she has worked with numerous Fortune 500 companies.

  • An Interview with Angela Kelly

    An Interview with Angela Kelly

    Sheldon Baker||August 31, 2012
    Angela Kelly is the president of Kelly Consulting, LLC under the parent company of AMK Enterprises. Ms. Kelly also serves as the sports chairman of the Pacific Technology Exchange (PTE), in charge of fundraising for their PTE scholarship program.

  • An Interview with Yadim Medore

    An Interview with Yadim Medore

    Sheldon Baker||August 24, 2012
    Yadim Medore is principal and creative director of Pure Branding, Inc. Under Mr. Medore’s direction, Pure Branding’s work has been honored with numerous awards including a Rebrand 100® global award and two Webby Awards, and returned significant ROI to its clients.

  • An Interview with John Lewis, Ph.D.

    An Interview with John Lewis, Ph.D.

    Sheldon Baker||August 17, 2012
    John E. Lewis, Ph.D. is an associate professor in the department of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine. He is the associate director of the Medical Wellness Center. He is also a scientific investigator at the Corporación de Lucha Contra el SIDA and the Fundación Valle del Lili in Cali, Colombia.

  • An Interview with Dr. Michael Smith

    An Interview with Dr. Michael Smith

    Sheldon Baker||July 27, 2012
    Dr. Michael Smith, MD is senior health science specialist with Life Extension in Fort Lauderdale, Fla., the world’s leading organization dedicated to extending the healthy human life span.

  • An Interview with Joel Rothman

    An Interview with Joel Rothman

    Sheldon Baker||July 6, 2012
    Joel Rothman is board certified in intellectual property law and a partner and co-chair of the Arnstein & Lehr Food, Beverage and Nutrition law practice group.

  • An Interview with Dr. Wael Massrieh

    An Interview with Dr. Wael Massrieh

    Sheldon Baker||June 15, 2012

  • An Interview with Neil Sullivan

    An Interview with Neil Sullivan

    Sheldon Baker||June 1, 2012
    Neil Sullivan is the director of sales for Kyowa Hakko USA, New York, NY. Kyowa Hakko is a world leader in fermentation, biotechnology and chemical synthesis, offering the highest quality line of amino acids and related ingredients.

  • An Interview with Heather Van Blarcom

    An Interview with Heather Van Blarcom

    Sheldon Baker||May 18, 2012
    Heather Van Blarcom recently joined dicentra and is a licensed attorney with more than 10 years of experience in the natural products industry. As a former general counsel, Van Blarcom brings a pragmatic and well-rounded expertise to issues impacting her clients. She has extensive experience in proactively helping companies achieve compliance with both FDA and FTC regulations including labeling and advertising review, claims review and substantiation, and GMP procedures and audits.

  • An Interview with The Caltons

    An Interview with The Caltons

    Sheldon Baker||May 11, 2012
    The Caltons are among the world’s leading experts on the topics of weight management, lifestyle medicine and micronutrient deficiency. Jayson B. Calton, PhD, FAAIM, DCCN, CMS, CISSN, BCIH, ROHP is a fellow of the American Association of Integrative Medicine, diplomate of the College of Clinical Nutrition, Board certified in integrative health and sports nutrition and one of only seven Registered Orthomolecular Health Practitioners in the U.S. Mira Calton, CN, FAAIM, DCCN, CMS, CPFC, BCIH is a licensed certified nutritionist, a fellow of the American Association of Integrative Medicine, diplomate of the College of Clinical Nutrition, a certified personal fitness chef and is board certified in integrative health.