Breaking News

Folic Acid Prior to Conception May Reduce Autism Risk in Kids

February 13, 2013

A new JAMA study finds that folic acid supplementation in mothers-to-be is even more crucial that previously considered.

A new study published in The Journal of the American Medical Association (JAMA), suggests that taking folic acid in the early stages of pregnancy may be even more crucial than previously considered. While folic acid has long been recommended for women trying to conceive, as it reduces the risk of neural tube defects in children, a Norwegian trial has found that folic acid supplementation prior to conception and throughout the early first trimester may drastically reduce the incidence of autism in children.
The population-based examination of the Norwegian Mother and Child Cohort Study (MoBa) assessed 85,176 children born between 2002-2008. Researchers evaluated the of folic acid intake of mothers from 4 weeks before to 8 weeks after the start of pregnancy, defined as the first day of the last menstrual period before conception.
At the end of follow-up, 270 children in the study sample had been diagnosed with autism spectrum disorders (ASDs): 114 with autistic disorder, 56 with Asperger syndrome, and 100 with PDD-NOS. In children whose mothers took folic acid, 0.10% (64/61,042) had autistic disorder, compared with 0.21% (50/24,134) in those unexposed to folic acid. The adjusted OR for autistic disorder in children of folic acid users was 0.61 (95% CI, 0.41-0.90). No association was found with Asperger syndrome or PDD-NOS, but power was limited. Similar analyses for prenatal fish oil supplements showed no such association with autistic disorder, even though fish oil use is associated with the same maternal characteristics as folic acid use.
These results led the study to conclude that use of prenatal folic acid supplements around the time of conception was associated with a lower risk of autistic disorder in the MoBa cohort. Although these findings cannot establish causality, they do support prenatal folic acid supplementation.
Researchers explained that while ethical considerations prohibit placebo-controlled randomized trials that eliminate folic acid, further observational studies of mothers who do and do not use supplements might be informative.

blog comments powered by Disqus
  • Nutricosmetics: Confined to Underdog Status or Opportunity to Outshine?

    Nutricosmetics: Confined to Underdog Status or Opportunity to Outshine?

    Nicholas Micallef , Euromonitor International||September 1, 2015
    Growing awareness that beauty is a byproduct of a healthy lifestyle is compelling more consumers to exercise and maintain a balanced diet.

  • Nature-Based Adipose Management Cosmetics

    Nature-Based Adipose Management Cosmetics

    John Stanek, Melinda Wochner and Shyam Gupta, CoValence Laboratories and Bioderm Research ||September 1, 2015
    The number of scientifically driven topical ingredients for body sculpting and adipose management is quickly growing.

  • Are You Aging Well?

    Are You Aging Well?

    Mark Menolascino, MD, Meno Clinic Center for Advanced Medicine||September 1, 2015
    How the future of anti-aging medicine and targeted nutritional supplementation will help achieve the optimal aging process.

  • 1Above Takes Flight

    1Above Takes Flight

    Lisa Olivo, Associate Editor||September 2, 2015
    A new line of functional drinks, shots and supplements targets weary travelers.

  • What’s in a Meal?

    What’s in a Meal?

    Jeremy Kerstetter, Assistant Editor||August 27, 2015
    Book reveals the correlation between certain foods, supplements and the successful management of pain and inflammation.

  • Industry Under Fire?

    Industry Under Fire?

    Jeremy Kerstetter, Assistant Editor||August 6, 2015
    CRN’s response to recent industry threats and the plan forward.