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Study Suggests Link Between Vitamin C Supplements & Kidney Stones

February 5, 2013

Research published in JAMA Internal Medicine indicated men who take vitamin C supplements regularly may run a higher risk of developing kidney stones.

New research from Karolinska Institutet in Sweden indicated that men who take vitamin C supplements regularly run a higher risk of developing kidney stones. The study, published in JAMA Internal Medicine, did not find an increased risk between kidney stones and multivitamins, which often ontain lower concentrations of vitamin C.
Research was based on data from a large population-based study of men from Västmanland and Örebro counties, who were monitored for 11 years. A total of 23,355 men were identified who had no history of kidney stones and who took either no dietary supplements or supplements in the form of vitamin C only. During the study period, 436 of the participants developed kidney stones that required medical attention. The researchers then compared the risk of kidney stones in vitamin C-takers with that in men who did not take any supplements. The analysis was then repeated for men who took multivitamins.
According to study authors, the results indicate that men who take vitamin C supplements (typically 1,000 mg per tablet) are twice as likely to develop kidney stones as men who do not take any dietary supplements. The risk was also found to increase with the frequency of vitamin C supplement use. The regular use of multivitamins was not found to be associated with the risk of kidney stones.
The researchers believe that both the dose and combination of nutrients with which the vitamin C is ingested are important. For this reason, the observed increase in risk does not apply to a normal dietary intake of vitamin C from fruit and vegetables. In Sweden, the RDI for vitamin C is 75 mg; the vitamin C content of supplements is commonly 1,000 mg per tablet, which is a considerably higher dose than is obtained through food.
"As with all research, the results should be corroborated by other studies for us to be really sure," said study leader Agneta Åkesson, Associate Professor at Karolinska Institutet's Institute of Environmental Medicine. "Nor can we say anything about whether women run the same risk as men.”

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