“Previous randomized controlled trials testing high doses of antioxidant supplements containing 1 to 3 compounds have failed to see any benefit on coronary heart disease,” the researchers reported. “One randomized controlled trial that studied the effect of a low-dose mixture of 5 antioxidant supplements (including 120 mg ascorbic acid, 30 mg vitamin E, 6 mg beta carotene, 100 μg selenium, and 20 mg zinc) did not observe any association with ischemic cardiovascular diseases. Notably, in a meta-analysis of high doses and very high doses of single supplements of vitamin A, β-carotene, or vitamin E tested in several randomized controlled trials, higher all-cause mortality was reported.”
An important part of the food antioxidant benefit is the synergistic effect. “In contrast to supplements of single antioxidants, the dietary total antioxidant capacity reflects all present antioxidants, including thousands of compounds, all of them in doses present in our usual diet, and even takes into account their synergistic effects,” explained the researchers.
While the researchers said their study findings were supported by several strengths, they conceded to some limitations, the most obvious of which was the exclusion of men. “The total antioxidant capacity has not been measured for Swedish foods; we used American ORAC values,” they wrote. “Antioxidant content may vary with geographic location and growing conditions. The observed association could be explained by consumption of fruit and vegetables; however, after this adjustment the association between total antioxidant capacity of diet and myocardial infarction remained statistically significant.
What’s more, the researchers did not have ORAC values for dietary supplements, thus, their results could only be translated to food items and not to antioxidant supplements. “Because of the prospective design, the misclassification is most likely to be nondifferential and therefore lead to attenuation of the observed association. Moreover, when we corrected for measurement error, an even stronger association was observed,” they wrote. “Furthermore, the observed inverse association could be due to a phenomenon in which women who eat an antioxidant-rich diet are more health conscious and have other healthy behaviors. When adjusting for several potential confounders such as smoking, physical activity, and educational level, the results remained statistically significant; however, we cannot rule out residual confounding by healthy lifestyle factors. Intervention studies would be needed to definitively determine the health effects of total antioxidant capacity.”